Small volumes of the carbon dioxide gas are introduced into the epidermis of the scalp with a blushing
technique (5-10° angle), only injecting the tip of the needle.
Carboxy therapy seems to be a promising therapeutic option for patchy alopecia areata and could be helpful as an adjuvant therapy of androgenic alopecia, but more than six sessions are required and adjuvants are recommended
for maintenance of the results.
Patients with androgenic alopecia, when treated with carboxy therapy, showed significant clinical and dermoscopic improvement after carboxy therapy with significant increase in hair density measured by digital dermoscopy.
Patients with alopecia areata, when treated with carboxy therapy, presented with significant reduction in dystrophic hair, black dots, yellow dots, and tapered hair coinciding with significant emergence of regrowing hair.